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    What are the risks of long-term PPI use for GERD symptoms in patients > 65 years?

    Devitt, Jessica
    Lyon, Corey
    Swanson, Sarah Beth
    DeSanto, Kristen
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    [PDF] JFP06804e18.PDF (69.89Kb)
    Date
    2019
    Format
    Article
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    Abstract
    Q: What are the risks of long-term PPI for GERD symptoms in patients > 65 years? EVIDENCE-BASED ANSWER: THE USE OF PROTON PUMP INHIBITORS (PPIs) to control gastrointestinal esophageal reflux disease (GRED) is significantly associated with increased risk of cardiovascular events such as acute myocardial infarction and myocardial ischemia, especially with treatment longer than 8 weeks (strength of recommendation [SOR]: A, systematic review of randomized, controlled trials [RCTs]). This summary is based on data extrapolated from studies on all adults because there is limited evidence that specifically addresses patients older than 65 years. Adults taking PPIs also appear to be at increased risk of Clostridium difficile infection, community-acquired pneumonia (CAP; with use for < 30 days), and fracture (SOR: B, systematic reviews of heterogeneous prospective and retrospective observational studies).
    URI
    https://hdl.handle.net/10355/67783
    Part of
    Journal of family practice, 68, no. 03 (2019): E18-E19.
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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    • Clinical Inquiries, 2019

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