dc.contributor.author | Dresang, Lee | eng |
dc.contributor.author | Vellardita, Lia | eng |
dc.date.issued | 2022-01 | eng |
dc.description.abstract | Q: Should we stop prescribing IM progesterone to women with a history of preterm labor? Evidence-based answer: YES, we should stop the routine prescribing of IM progesterone to prevent preterm delivery. A 2003 randomized controlled trial (RCT) found that weekly intramuscular (IM) 17 hydroxyprogesterone (17-OHP) for women with a singleton pregnancy and a history of spontaneous preterm delivery decreased the preterm delivery rate by 34% (strength of recommendation [SOR]: B, single RCT). However, the follow-up 2020 PROLONG RCT did not find that 17-OHP prevents preterm birth or improves neonatal outcomes. This held true for subgroup analyses (SOR: B, single larger RCT). (Notably, though, the PROLONG study had very few Black participants when compared with the 2003 study.) The US Food and Drug Administration (FDA) has recommended withdrawing 17-OHP from the market. The American College of Obstetricians and Gynecologists (ACOG) and the Society for Maternal-Fetal Medicine (SMFM) have released statements supporting shared decision-making with women regarding the prescribing of 17-OHP for preterm delivery prevention (SOR: C, expert opinion). | eng |
dc.description.bibref | Includes bibliographical references | eng |
dc.description.statementofresponsibility | Lee Dresang, MD (University of Wisconsin Department of Family Medicine and Community Health, Madison) Lia Vellardita, MA (Ebling Library, University of Wisconsin School of Medicine and Public Health, Madison) | eng |
dc.format.extent | 3 pages | eng |
dc.identifier.citation | The journal of family practice 71 (1) 2022 E15-E17 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/91368 | |
dc.language | English | eng |
dc.publisher | Family Physicians Inquiries Network | eng |
dc.relation.ispartofcollection | Clinical Inquiries, 2022 (MU) | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.title | Should we stop prescribing IM progesterone to women with a history of preterm labor? | eng |
dc.type | Article | eng |