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Enterobactin export in escherichia coli via P43 (ents) and associated components
(University of Missouri--Columbia, 2006)
Ferric iron, critical for the metabolic functions of many microorganisms, is generally insoluble at neutral pH or quickly complexed by host iron storage proteins. To acquire necessary ferric iron against harsh competition ...
The innate immune response and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2005)
There are two major divisions of the human immune system: the adaptive and the innate immune systems. The adaptive immune responses are directed against specific pathogens and are essential for control and elimination of ...
Examination of specific amino acid residues of desulfovibrio desulfuricans cytochrome C₃ in electron transfer
(University of Missouri--Columbia, 2005)
Sulfate-reducing bacteria (SRB) are strictly anaerobic microorganisms present throughout the environment. These microorganisms are able to utilize a variety of electron donors and couple the oxidation of those compounds ...
Effects of treprostinil sodium in a monocrotaline-induced rat model of pulmonary hypertension
(University of Missouri--Columbia, 2005)
Treprostinil is a prostacyclin analog currently used in the treatment of pulmonary hypertension. Although clinical studies show treprostinil to be a successful therapy for pulmonary hypertension, little information exists ...
Elucidating the mechanisms and dynamics of drug-mediated inhibition and latency reversal in HIV-1 (HIV-1)
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Human Immunodeficiency Virus Type-1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome, a disease that causes the host to succumb ...
Characterization of the role of adenovirus-5 (Ad-5) gene products E2A, E4ORF6 and VA RNA on adeno-associated virus type 5 (AAV5) transcription, translation and replication
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] AAV5 is the most distinct serotype of the AAVs differing from the prototype virus AAV2 at the nucleotide level. We show that in AAV5 the Rep transcripts ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically ...
Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine
(University of Missouri--Columbia, 2008)
Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
Role of Sds22 in the regulation of protein phosphatase-1 in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] GLC7 encodes the catalytic subunit of protein phosphatase 1 (PP1) in the budding yeast Saccharomyces cerevisiae. Glc7 binds different regulatory ...
Teaching T cells to remember : the role of antigen presenting cells in the development of CD4+ T cell memory
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recent studies in our lab suggest that the number of divisions a naive T cell undergoes at the time of initial stimulation with antigen (Ag) affects ...
The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses
(University of Missouri--Columbia, 2008)
Dendritic cells (DCs) play an important role as a link between innate and adaptive immunity through their abilities to detect infection and to prime naïve T cells (signal 1 and 2). They not only activate naïve T cells, ...
An essential role in germline development for a P-granule associated novel protein in the model organism Caenorhabditis elegans and RNAi in the ubiquitous parasitic nematode Ascaris suum
(University of Missouri--Columbia, 2009)
The germline RNA helicases (GLHs) are constitutive components of P granules and important for fertility in C. elegans. Discovered as a GLH-1 partner, the P-granule associated novel protein (PAN-1) is important both in ...
Functional characterization of two putative mobile elements of the 'Mycoplasma mycoides cluster'
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Horizontal gene transfer has played a major role in bacterial evolution, including in the genus Mycoplasma, which is comprised of some of the simplest ...
Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2008)
This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ...
Energy metabolism and uranium (VI) reduction by Desulfovibrio
(University of Missouri--Columbia, 2005)
Sulfate reducing bacteria (SRB) of the genus Desulfovibrio can breathe uranium in a manner similar to the way in which we (human beings) breathe oxygen. In respiration, we transfer electrons from food to oxygen, producing ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Characterization of cellular pathways in spinal muscular atrophy
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is an autosomal recessive genetic disease, and is the leading genetic cause of death in infants. SMA is a severe ...