Search
Now showing items 1-20 of 48
A novel PCR based DNA microanalyzer system for detection of viral genome
(University of Missouri--Columbia, 2006)
A micro-fluidic assay to quickly analyze microscopic samples of DNA is being developed for field applications. It consists of a micro-PCR chamber, micropumps, and micro-heaters. Additional components of the device include ...
Development of a capillary based helicobacter hepaticus biosensor
(University of Missouri--Columbia, 2006)
Helicobacter hepaticus causes hepatitis in mice. Infections with H. hepaticus can invalidate animal research studies and early detection helps curtail the spread of infection. The objective of this study was to develop a ...
Photoacoustic detection of metastatic melanoma in the human circulatory system
(University of Missouri--Columbia, 2006)
Detection of disseminating tumor cells can function as an early warning system, alerting the metastatic spread or recurrence of the disease. Early detection of such cells can result in preventative treatment of the disease ...
Optical glucose nanobiosensor encapsulated in erythrocytes
(University of Missouri--Columbia, 2007)
An implantable glucose biosensor encapsulated in erythrocytes, Red Blood Cells (RBC), will become a method for continuously measuring blood glucose concentration in diabetics. In 2005, the American Diabetes Association ...
Optical stimulation of quantal exocytosis on transparent microchips
(University of Missouri--Columbia, 2007)
Photorelease of caged Ca²⁺ is a uniquely powerful tool to study the dynamics of Ca²⁺-triggered exocytosis from individual cells. Using photolithography and other microfabrication techniques, we have developed transparent ...
Synthesis and application of semiconductor quantum dots in novel sensing applications
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] This thesis details the synthesis of CdSe/ZnS semiconductor nanocrystals (quantum dots). These quantum dots (QDs) show very interesting optical properties ...
Detection of CD4 and CD8 t-lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator biosensor
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] We have demonstrated label-free detection of CD4+ and CD8+ T-Lymphocytes and HER2 breast cancer biomarker using the opto-fluidic ring resonator (OFRR) ...
Ratiometric techniques to determine fluid viscosity using molecular rotors
(University of Missouri--Columbia, 2007)
Molecular rotors exhibit viscosity-dependent quantum yield, potentially allowing measurements of fluid viscosity in non-mechanical manner. Several diseases are accompanied by blood plasma viscosity changes; therefore, a ...
Quantification of cell attachment on different materials as candidate electrodes for measurement of quantal exocytosis
(University of Missouri--Columbia, 2008)
A high throughput lab-on-a-chip device is being developed for single cell capture for the purpose of high time resolution quantal exocytosis measurement with high probability of cell docking. This device makes use of DLC ...
Aptamer encoded nanopores as single molecule sensors
(University of Missouri--Columbia, 2008)
We have created a low noise, calibrated, molecular-scaled pore. The nanopore is formed either by micro-forge polishing or external penetration of the nanocavity sealed in the pipette terminal. The nanopore fabrication is ...
Development of electrospun synthetic bioabsorbable fibers for a novel bionanocomposite hernia repair material
(University of Missouri--Columbia, 2008)
In order to create a more durable and biocompatible hernia repair mesh, a novel bionanocomposite material based on the crosslinking of bioabsorbable polymer fibers to decellularized porcine diaphragm tissue is proposed. ...
Visible reflectance spectroscopy to observe the effect of copper embedded socks on erythema in feet
(University of Missouri--Columbia, 2008)
Objective assessment of skin characteristics is necessary to aid in the clinical detection of erythema and debilitating skin conditions. The ability to treat different skin pathologies based on individual patient skin ...
Properties of extruded white corn flour - high amylose corn starch puffs
(University of Missouri--Columbia, 2008)
This study was conducted to determine the effect of high-amylose corn starch in corn puffs on the extrusion parameters, product and textural properties and the glass transition temperature. The data was analyzed in a ...
Single-molecule investigation and nanopore-integrated biochip
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Chlorella-encoded membrane protein Kcv was synthesized and purified in vitro. By co-synthesis and assembly of wild type with tagged version of Kcv, ...
The role of sodium-calcium exchanger in the electrical activity of embryonic chicken heart
(University of Missouri--Columbia, 2008)
Heart is one of the most important organs of the body and also it is one of the first organs during to the development. The electrical activity of heart is essential for its function. It has been shown that the sodium-calcium ...
Fibrous soy protein meat analog from low moisture twin-screw extrusion
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Mixtures of soy protein isolate (SPI), defatted soy flour, and wheat flour were extruded at 34% (w.b.) moisture using a twin-screw extruder. A 3x3x3 ...
A ratiometric fluorometer for reduced sensitivity against solvent artifacts
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] When measuring fluorescence emission intensity, both the dye concentration and the optical absorption properties of the solvent influence the measured ...
Polyurethane foams from novel soy-based polyols
(University of Missouri--Columbia, 2008)
Polyurethane foams and molded plastic films were prepared by reacting isocyanates with polyols containing 50% of vegetable oil-based polyols and 50% of petroleum-based polyols. The vegetable oil-based polyols included ...
Gating of CFTR chloride channels : distinct closed states revealed by the action of AMP-PNP
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The CFTR chloride channel is gated by ATP through an irreversible gating cycle driven by an input of free energy of ATP hydrolysis. The open state of ...
Optical reflectance in fibrous tissues and skeletal muscles
(University of Missouri--Columbia, 2008)
We studied diffuse optical reflectance in two anisotropic biological tissues: high moisture soy extrudates and skeletal muscles. High moisture extrusion of soy proteins can produce healthy alternative protein sources that ...