Pharmacological action of acetanilide, antipyrine & acetphenetidin on cardiac muscle
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It is a well-known fact that acetanilide and the antipyrine series, when administered in clinical cases, for antipyretic purposes, often have untoward and unexpected accompanying actions. These associated influences have not yet been fully inquired into by experimental methods. There has grown up a consensus of opinion, based on general evidence, that the circulatory system, especially the heart is impaired and that the oxygen carrying power of the blood cells is lessened because of a chemical change. It is the purpose of this paper to present the results of a series of experiments on the action of these drugs on isolated cardiac muscle, both on tissue known to contain nerve ganglia, the sinus; and on that free from nerve ganglia, the apex strip of the ventricle.