Browsing Dissertations (MU) by Thesis Department "Medical Pharmacology and Physiology (MU)"
Now showing items 1-20 of 46
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Alcohol induced histone acetylation mediated by histone acetyl transferase GCN5 in liver
(University of Missouri--Columbia, 2008)Although several mechanisms have identified for alcoholic liver disease, at present there are no precise mechanisms for liver injury. We have observed that surrogate alcohols increases histone H3 acetylation selectively ... -
Antecedent hydrogen sulfide elicits an anti-inflammatory phenotype in postischemic murine small intestine
(University of Missouri--Columbia, 2007)Ischemia followed by reperfusion (I/R) is now well-recognized as one form of acute inflammation in which leukocytes play a key role. Preconditioning is a phenomenon through which antecedent exposure to a particular stimulus ... -
Attenuation of rapid onset vasodilation with advanced age : roles of adrenergic and endothelial signaling
(University of Missouri--Columbia, 2016)Rapid onset vasodilation (ROV) occurs immediately in response to skeletal muscle contraction and initiates a prompt increase in blood flow and oxygen delivery that facilitate the transition to exercise. Muscle blood flow ... -
Cardiomyocyte calcium and stress-induced ventricular arrhythmia
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy and is caused by mutations in the dystrophin gene. Subclinical signs of cardiac disease present early and usually progress ... -
Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of ... -
CFTR gating mechanism : the role of dimerization of nucleotide binding domains
(University of Missouri--Columbia, 2009)The chloride channel, cystic fibrosis transmembrane conductance regulator (CFTR) has two membrane spanning domains (MSD), forming the channel pore, and two nucleotide binding domains (NBD), controlling the channel gating ... -
Collecting lymphatic vessel permeability to albumin and its modification by natriuretic peptides
(University of Missouri--Columbia, 2010)Microvascular exchange is the process whereby the blood provides the tissues of the body nutrients for cellular metabolism, macromolecules essential for fighting infection, and waste removal. However, these constituents ... -
Contribution of AT1R mechanoactivation to the arterial myogenic response and its regulation by RGS5 protein in skeletal muscle arterioles
(University of Missouri--Columbia, 2015)Although intracellular mechanisms underlying the arteriolar myogenic response have been well-defined, the mechanotransduction events transducing the mechanical stimulus remain unclear. Recently, ligand-independent activation ... -
Design, synthesis, and evaluation of radiolabeled bombesin conjugates for the diagnosis of breast cancer
(University of Missouri--Columbia, 2009)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Gastrin-releasing peptide (GRP) receptors are overexpressed on approximately two thirds (62-71%) of primary breast carcinomas and all (100%) of the ... -
EC-SGK1 and EnNaC mediate vascular stiffening
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Vascular stiffening is an independent predictor of cardiovascular diseases, the leading cause of death worldwide. High dietary salt intake has been shown to increase vascular stiffness in humans, ... -
Effects of ischemic metabolites and chronic exercise on cardiac myocyte function
(University of Missouri--Columbia, 2005)During times of low blood flow (ischemia), concentrations of wastes increase in tissues, which can lead to decreased striated muscle contractile function. Acute cardiac contractile dysfunction during ischemia is likely ... -
The effects of physical activity on adipose tissue metabolism and DNA methylation
(University of Missouri--Columbia, 2009)The increased prevalence of obesity and diabetes threatens both the real and economic health of Western counties. There were two major goals of this dissertation, 1) to determine if in response to inactivity and hyperphagia ... -
The effects of sex and ovarian hormones on arterial baroreflex control of blood pressure in humans
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The arterial baroreceptors are responsible for mediating rapid reflex adjustments to acute cardiovascular stressors via modulating autonomic nervous ... -
Efficacy of TNF inhibitor treatment in a model of heart failure and resulting cachexia
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aim this dissertation was to explore the efficacy of tumor necrosis factor (TNF) inhibitors in attenuating increases in both anorexia and the ... -
Exercise, FGF21, and PGC-1 : roles in hepatic metabolism
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The liver is instrumental in maintaining euglycemia during times of fasting and exercise, and in-turn exercise is a stimulus that challenges the liver ... -
Expression of IGF2R, IGF2, TGFß, and uPAR in a rat model of obesity /
(University of Missouri--Columbia, 2017)We tested the hypothesis that induction of obesity in lean Long Evans Tokushima Otsuka (LETO) and obesity-prone Otsuka Long Evans Tokushima Fatty (OLETF) would cause the insulin growth factor 2 receptor (IGF2R) and factors ... -
Functional and pharmacological importance of the composite ATP binding site 1 in CFTR chloride channels
(University of Missouri--Columbia, 2010)The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel whose defects cause the deadly genetic disease cystic fibrosis (CF). Like other ATP binding cassette (ABC) proteins, CFTR encompasses ... -
Histone H3 phosphorylation and phosphoacetylation in the liver of rats treated in vivo with acute ethanol
(University of Missouri--Columbia, 2011)Epigenetic histone modification is emerging as a critical player in the cellular actions of ethanol. In this context, we administered ethanol intraperitoneally to rats, to mimic binge drinking in humans. A dose response ... -
Lipotoxicity in smooth muscle
(University of Missouri--Columbia, 2006)Atherosclerosis and bladder dysfunction can both result from the high lipid levels that occur with obesity and diabetes and can cause cell dysfunction and death, termed lipotoxicity, in various cell types. However, ... -
Maladaptation of cardiac and skeletal muscle in chronic disease : effects of exercise
(University of Missouri--Columbia, 2007)The human genome is adapted for daily physical activity (85). Thus, a sedentary lifestyle is capable of promoting detrimental consequences to human health. The linkage between lack of sufficient physical activity and the ...