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Exposure Assessment for Endocrine Disruptors: Some Considerations in the Design of Studies
(National Institute of Environmental Health Sciences, 2003)
In studies designed to evaluate exposure-response relationships in children's development from conception through puberty, multiple factors that affect the generation of meaningful exposure metrics must be considered. These ...
In vitro and in vivo approaches to tumor targeting by phage display
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Approximately 30% of breast cancers are linked with the over-expression of ErbB2. Because of its critical role in signal transduction, the progression ...
Evaluating the Effects of Endocrine Disruptors on Endocrine Function during Development
(National Institute of Environmental Health Sciences, 1999)
The major concerns with endocrine disruptors in the environment are based mostly on effects that have been observed on the developing embryo and fetus. The focus of the present manuscript is on disruption of three hormonal ...
Exposure to a Low Dose of Bisphenol A during Fetal Life or in Adulthood Alters Maternal Behavior in Mice
(National Institute of Environmental Health SciencesEnvironmental Health Perspectives, 2002)
Maternal behavior in mammals is the result of a complex interaction between the lactating dam
and her developing offspring. Slight perturbations of any of the components of the mother-infant interaction may result in ...
The Protein Storage Vacuole: A Unique Compound Organelle
(The Journal of Cell Biology, 2001)
Storage proteins are deposited into protein storage vacuoles (PSVs) during plant seed development and maturation and stably accumulate to high levels; subsequently, during germination the storage proteins are rapidly ...
Bacteriophage HP2 of Haemophilus influenzae
(American Society for Microbiology, 2002)
Temperate bacteriophages effect chromosomal evolution of their bacterial hosts, mediating rearrangements and the acquisition of novel genes from other taxa. Although the Haemophilus influenzae genome shows evidence
of ...
Why Public Health Agencies Cannot Depend on Good Laboratory Practices as a Criterion for Selecting Data: The Case of Bisphenol A
(National Institute of Environmental Health Sciences, 2009)
We reviewed differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories to identify hazards and ...
SIRT1 deacetylation regulates NFAT transcriptional activity
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The class III histone deacetylase SIRT1 plays important roles in aging, metabolism and biological clock control. We have recently demonstrated that ...
A study of the role of the Atg8 protein in autophagic vesicle formation
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Autophagy is the term used to refers to an catabolic cellular cleanup process through the lysosomal machinery. During autophagy portions of cytoplasm ...
Examination of exogenous estrogenic chemical exposure and altered fetal nutrition in the CD-1 mouse fetus
(University of Missouri--Columbia, 2009)
My dissertation examines two issues related to disruption of fetal growth: exposure to exogenous estrogenic chemicals and altered nutrition. My first set of studies was aimed at manipulating isoflavones in feed on serum ...
Investigations into the cause of pollen abortion in maize CMS-C
(University of Missouri--Columbia, 2009)
Cytoplasmic male sterility type C (CMS-C) is atypical compared to other CMS types as no novel chimeric transcript or protein has been found correlating with the phenotype. However, a tassel-specific decrease for both ATP6 ...
A multi-scale investigation of ecologically relevant effects of agricultural runoff on amphibians
(University of Missouri--Columbia, 2008)
Modification of landscapes for agricultural production can introduce agrochemicals into surface waters and degrade aquatic habitats used by many amphibians for breeding and larval development. Although many ecotoxicological ...
Age effects on reproductive behavior in the treehopper umbonia crassiscornis (Hemipera: membracidae)
(University of Missouri--Columbia, 2007)
In many animal species females select mates based on male age. This choice is often linked to the reproductive benefits females derive. Age-based choice is also influenced by variation in the ability of males to find and ...
Mating systems in Nicotiana longiflora and N. Plumbaginifolia : the effect of interspecific interactions
(University of Missouri--Columbia, 2008)
The research presented here was focused on the effects of interactions between Nicotiana longiflora and N. plumbaginifolia on their mating systems. First, I conducted a series of observations and pollination experiments ...
Chromatin-level regulation of the maize purple plant1 gene
(University of Missouri--Columbia, 2008)
In eukaryotes, gene expression is controlled at the chromatin level by mechanisms that are not yet well understood. This study addressed some of the unanswered questions about chromatin-level gene regulation. In maize, the ...
Experimental evaluation of apparent tissue surface tension based on the exact solution of the Laplace equation
(IOP, 2008)
The notion of apparent tissue surface tension offered a systematic way to interpret
certain morphogenetic processes in early development. It also allowed deducing quantitative information on cellular and molecular parameters ...
A study of readthrough therapy for spinal muscular atrophy in a transgenic mouse model
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Spinal Muscular Atrophy (SMA) is due to the loss of the telomeric survival motor neuron gene (SMN1) and results in degeneration of motor neurons, ...
Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron
(Society for Neuroscience, 2010)
Similar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell ...
Collective offspring-parent signaling in a social treehopper : mechanisms, patterns and function
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] I investigated the properties of collective behavior in a group-living insect, including the patterns of group behavior, the function of group level ...
Biogenesis of the Protein Storage Vacuole Crystalloid
(The Journal of Cell Biology, 2000)
We identify new organelles associated with the vacuolar system in plant cells. These organelles are defined biochemically by their internal content of three integral membrane proteins: a chimeric reporter protein that moves ...