Search
Now showing items 61-80 of 129
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ...
Alternative translation and alternative RNA processing mechanism in parvovirus RNA processing
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Viruses as obligate intracellular metabolic parasite require the capacity to orchestrate and modulate the host environment either in the nucleus or ...
The role of sphingosine kinase in influenza virus mediated inflammasome activitation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Influenza viruses continue to pose a grave burden on the global health and economy. Dysregulated innate immune system can lead to rapid infiltration ...
Posttranscriptional gene regulation by the RNA binding protein HuR in two disease models : allergic asthma and breast cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The RNA binding protein HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Examination of specific amino acid residues of desulfovibrio desulfuricans cytochrome C₃ in electron transfer
(University of Missouri--Columbia, 2005)
Sulfate-reducing bacteria (SRB) are strictly anaerobic microorganisms present throughout the environment. These microorganisms are able to utilize a variety of electron donors and couple the oxidation of those compounds ...
Effects of treprostinil sodium in a monocrotaline-induced rat model of pulmonary hypertension
(University of Missouri--Columbia, 2005)
Treprostinil is a prostacyclin analog currently used in the treatment of pulmonary hypertension. Although clinical studies show treprostinil to be a successful therapy for pulmonary hypertension, little information exists ...
Lipid mediators in the development and resolution of experimental lyme arthritis
(University of Missouri--Columbia, 2007)
The focus of my graduate studies was to determine the contribution of members of the eicosanoid cascade, namely the cyclooxygenase enzymes, to the regulation of experimental Lyme arthritis pathology. Using COX-2-specific ...
Energy metabolism and uranium (VI) reduction by Desulfovibrio
(University of Missouri--Columbia, 2005)
Sulfate reducing bacteria (SRB) of the genus Desulfovibrio can breathe uranium in a manner similar to the way in which we (human beings) breathe oxygen. In respiration, we transfer electrons from food to oxygen, producing ...
Insights into understanding malaria parasite biology : characterization of the Plasmodium protein, MAL13P1.319
(University of Missouri--Columbia, 2011)
Malaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. ...
Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs ...
Identification and characterization of Bacillus anthracis spore-associated proteins
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bacillus anthracis is a Gram-positive, rod-shaped, spore-forming bacterium and the etiological agent of anthrax. Spore formation is essential for ...
Studies on the development of a bacillus endospore-based microparticle vaccine platform
(University of Missouri--Columbia, 2011)
The rapid and safe immunization of populations is critical in response to emerging infectious diseases or biological attacks. Currently, many subunit vaccines are insufficiently immunogenic to protect against pathogen ...
Characterization of the role of the DNA damage response pathway in parvoviral replication
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] We report that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DNA damage response ...
The roles of ERK pathway localization and the regulation of [beta]-catenin/Bcl-XL kinetic in thymic selection
(University of Missouri--Columbia, 2011)
Thymocytes undergo a process of development that serves to favor the differentiation of T-cells bearing self-MHC (major histo-compatibility complex) restricted T-cell receptors (TCR). Signaling through the TCR is crucial ...
Characterization of HIV-1 reverse transcriptase drug resistance connection subdomain mutation N348I
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Connection subdomain mutations are a recently discovered class of reverse transcriptase (RT) drug resistance mutations which are positioned at some ...
The RNA binding protein HuR : novel mouse models and T cell targets
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Posttranscriptional gene regulation is an important mechanism of controlling mRNA expression and protein production. The RNA binding protein has been ...
Mechanisms of central and peripheral immune tolerance
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The decision of a stem cell to develop into the myeloid or lymphoid lineage has been postulated to occur in the bone marrow. However, a marker of ...
Piecing together the Plasmodium falciparum genome puzzle : characterization of genes/proteins, PFE0565w and PF11_0394
(University of Missouri--Columbia, 2011)
Malaria is still a significant problem around the world and, thus, better control methods are in great need. A key stage in the Plasmodium life cycle is the sporozoite because it exhibits dual infectivity in both the ...