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Now showing items 101-120 of 129
Mechanisms of immunity and inflammation in Brucella-induced arthritis
(University of Missouri--Columbia, 2018)
"Treatment of unresolved sterile arthritis such as rheumatoid arthritis or osteoarthritis involves eliminating or dampening host inflammatory responses. While inflammation may inflict severe articular pathology to the host ...
Mechanisms of clostridial toxin binding and translocation
(University of Missouri--Columbia, 2018)
The bacterial genus Clostridium consists of over 150 species of anaerobic, fermentative, spore-forming bacilli. Clostridial species produce up to 20% of all known bacterial exotoxins, which serve as important virulence ...
Synergistic inactivation of Escherichia coli and phage T7 by near-ultraviolet radiation and hydrogen peroxide
(University of Missouri--Columbia, 1979)
A non-1ethal concentration of H2O2 enhances NUV inactivation of Escherichia coli and its phages. Three distinct types of synergistic interaction were identified. Conditions were established which allowed the specific ...
Comparative study of Human Immunodeficiency Virus type 1 and type 2 single and dual infections
(University of Missouri--Columbia, 2020)
Human Immunodeficiency Virus (HIV) type 1 and type 2 are two related lentiviruses that have strikingly divergent features in terms of transmission rates, distribution, pathogenesis, and clinical outcomes. In places where ...
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias ...
L-tryptophan photoproduct : effect on DNA replication and DNA repair in Escherichia coli
(University of Missouri--Columbia, 1974)
"This study was stimulated by two important discoveries. The first of these came to a focus when it was observed that recombinationless (rec) mutants of bacteria were readily killed by near-UV irradiation. Recognition of ...
A role played by sex in innate immune memory and disease severity
(University of Missouri--Columbia, 2023)
While immunological memory has traditionally been understood to be solely within the purview of adaptive immunity, recent evidence has shown that a type of "memory" exists in innate immune cells, as a prior insult can lead ...
Interplay of Bacillus anthracis spore proteins in the assembly process of the exosporium
(University of Missouri--Columbia, 2023)
Spores are the infectious form of the zoonotic pathogen, Bacillus anthracis. The outermost layer of these spores is the exosporium. It consists of a basal layer (major structural proteins are ExsY, CotY, BxpB, and ExsFB) ...
Yeast mutants containing elevated methionine
(University of Missouri--Columbia, 1983)
Yeasts are deficient in methionine which restricts the nutritive value of the protein. The objective of this research was to produce a methionine-rich mutant. Mutants of Candida tropical is ATCC 1369, Candida tropica!is ...
Magnitude of STING Signaling Determines CD8 T cell Memory
(University of Missouri--Columbia, 2019)
Memory CD8+ T cells are critical for long-term protection against intracellular pathogens and tumors. STING signals enable the transcription of pro-inflammatory molecules, such as type I IFNs, in response to nucleic acids ...
Persistence of plague : determining which environmental factors contribute to maintenance of Yersinia pestis within sylvatic cycles
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Plague is a prioritized zoonotic disease caused by Yersinia pestis, a gram-negative bacterium. Sylvatic cycles of rodent host and flea vectors have established endemic foci responsible for the ...
Mechanisms of inflammation resolution in a murine model of Lyme arthritis
(University of Missouri--Columbia, 2023)
In some patients, Lyme arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi ...
Lipid mediators in the development and resolution of experimental lyme arthritis
(University of Missouri--Columbia, 2007)
The focus of my graduate studies was to determine the contribution of members of the eicosanoid cascade, namely the cyclooxygenase enzymes, to the regulation of experimental Lyme arthritis pathology. Using COX-2-specific ...
Rational design of split gene vectors to expand the packaging capacity of adeno-associated viral vectors
(University of Missouri--Columbia, 2007)
Adeno associated viruses (AAV) have recently been demonstrated as a very promising gene delivery vehicle. But the limited packaging capacity of AAV vectors (4̃.7kb) hinders their application for diseases involving large ...
Transcription regulation of adeno-associated viruses
(University of Missouri--Columbia, 2007)
The small genome size of adeno-associated viruses demand efficient gene regulation achieved by various strategies. This research compared these strategies from AAV2, AAV5 and bovine-AAV, and found that AAV2 capsid promoter ...
Immunity in the newborn : control by IL-13 receptor and dendritic cells
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Neonates are susceptible to microbial infections and allergic reactions due to lack of Th1 immunity. Utilization of a TCR transgenic T cell transfer ...
T cells from immunological memory to autoimmune disease
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] T cells are one of the key components of the acquired immune response. These cells are instrumental in fighting bacterial and viral infections. ...
Serum resistance of an invasive nontypeable H. influenzae
(University of Missouri--Columbia, 2004)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Since the introduction of Haemophilus influenzae b polysaccharide-protein conjugate vaccines, the incidence of invasive H. influenzae disease dramatically ...
Enterobactin export in escherichia coli via P43 (ents) and associated components
(University of Missouri--Columbia, 2006)
Ferric iron, critical for the metabolic functions of many microorganisms, is generally insoluble at neutral pH or quickly complexed by host iron storage proteins. To acquire necessary ferric iron against harsh competition ...
Analysis of interactions between the germline RNA helicases (GLHs) and their regulators KGB-1 and CSN-5 in Caenorhabditis elegans
(University of Missouri--Columbia, 2006)
The Caenorhabditis elegans germline RNA helicases (GLHs) are constitutive components of P granules, non-membranous aggregates of protein and RNA that segregate with the nematode germline. The GLHs are critical for fertility. ...